A client does not run a scheduled backup
A manual backup appears to run successfully
No scheduled backup appears in Jobs › Scheduled Jobs for the affected client
Things to check
Make sure the client has a schedule enabled under Clients › Edit (you can also see this information in Clients › Summary under the Schedule Column)
Look over the schedule in Settings › Backups › Job Schedules to confirm the schedule has the proper schedules configured for backups
Check the CFA time in Settings › Basic › Appliance Status, and change it to match the servers if needed by going to Settings › Basic › Date/Time
Steps to resolve
This issue is commonly attributed to something getting hung up during the initial client configuration.
If none of the above steps resolve the issue, it is recommended to create a new client and test to see if the same behavior is observed with the new client.
Also, you may try applying the different schedule to the client, click Apply, then Activate configuration, apply the required schedule, and activate it.